Sie sind hier
E-Book

Pentamycin - a new option for the treatment of infections with Trichomonas vaginalis?

AutorMarkus Kranzler
VerlagGRIN Verlag
Erscheinungsjahr2012
Seitenanzahl184 Seiten
ISBN9783656145653
FormatPDF/ePUB
Kopierschutzkein Kopierschutz/DRM
GerätePC/MAC/eReader/Tablet
Preis39,99 EUR
Diplomarbeit aus dem Jahr 2011 im Fachbereich Biologie - Mikrobiologie, Molekularbiologie, Note: 1, Universität Wien, Sprache: Deutsch, Abstract: The protozoan parasite Trichomonas vaginalis is the causative agent of trichomonosis which is - with more than 170 million new cases each year - the most prevalent non-viral sexually transmitted disease (STD) worldwide. Although trichomonosis is not a primarily lethal disease, the clinical picture can include severe urogenital inflammations. Chronic infections have been associated with cervical/prostate cancer and a predisposition of HIV infections. In case of pregnancy, chronic infections can also lead to preterm delivery and low birth weight. For more than 50 years, metronidazole, a nitroimidazole antibiotic, has been in use for the treatment of trichomonosis. It is applied orally and although it is mostly compliant, it can have serious side effects. It is also not applicable for pregnant women due to its ability to pass the placenta. Furthermore, an increasing number of emerging metronidazoleresistant T. vaginalis strains has lead to more treatment failures in the last few years. To this day, however, there is no effective alternative drug against trichomonosis available. Pentamycin is a polyene antimycotic and has been in use in the treatment of candidiasis, in preliminary studies it also turned out to be effective against trichomonads. The aim of this study was to evaluate the efficacy of pentamycin against T. vaginalis and the ability to develop resistances in vitro. For these purposes, the dose-effect relationship between pentamycin and four differently metronidazole-sensitive T. vaginalis strains was investigated. Moreover, the protein composition before and after the treatment was compared. To induce resistance, strains were treated with sublethal concentrations of pentamycin within a time of six months. It could be shown that pentamycin is highly effective against T. vaginalis. A 100% eradication of trichomonads was reached with a concentration of 15 ;g/ml and an incubation time of 1h. All four differently metronidazole-sensitive strains showed almost the same sensitivity to pentamycin. The comparison of the protein profiles of untreated and treated cells analysed by SDS-PAGE showed that the mode of action of pentamycin is based on an interaction and subsequent damage of the cell membrane which consequently leads to total lysis and death of the cell. [...]

Kaufen Sie hier:

Horizontale Tabs

Blick ins Buch

Weitere E-Books zum Thema: Biologie und Genetik - Lehre und Forschung

Weitere Zeitschriften

Bibel für heute

Bibel für heute

BIBEL FÜR HEUTE ist die Bibellese für alle, die die tägliche Routine durchbrechen wollen: Um sich intensiver mit einem Bibeltext zu beschäftigen. Um beim Bibel lesen Einblicke in Gottes ...

crescendo

crescendo

Die Zeitschrift für Blas- und Spielleutemusik in NRW - Informationen aus dem Volksmusikerbund NRW - Berichte aus 23 Kreisverbänden mit über 1000 Blasorchestern, Spielmanns- und Fanfarenzügen - ...

ea evangelische aspekte

ea evangelische aspekte

evangelische Beiträge zum Leben in Kirche und Gesellschaft Die Evangelische Akademikerschaft in Deutschland ist Herausgeberin der Zeitschrift evangelische aspekte Sie erscheint viermal im Jahr. In ...

rfe-Elektrohändler

rfe-Elektrohändler

rfe-Elektrohändler ist die Fachzeitschrift für die CE- und Hausgeräte-Branche. Wichtige Themen sind: Aktuelle Entwicklungen in beiden Branchen, Waren- und Verkaufskunde, Reportagen über ...

building & automation

building & automation

Das Fachmagazin building & automation bietet dem Elektrohandwerker und Elektroplaner eine umfassende Übersicht über alle Produktneuheiten aus der Gebäudeautomation, der Installationstechnik, dem ...